Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine performs at least as well as the homologous vaccination...

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Main Authors:	Alexandra J. Spencer, Paul F. McKay, Sandra Belij-Rammerstorfer, Marta Ulaszewska, Cameron D. Bissett, Kai Hu, Karnyart Samnuan, Anna K. Blakney, Daniel Wright, Hannah R. Sharpe, Ciaran Gilbride, Adam Truby, Elizabeth R. Allen, Sarah C. Gilbert, Robin J. Shattock, Teresa Lambe
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/b9635c93599e4d14abcf385c2298f08d
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spelling	oai:doaj.org-article:b9635c93599e4d14abcf385c2298f08d2021-12-02T14:58:43ZHeterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice10.1038/s41467-021-23173-12041-1723https://doaj.org/article/b9635c93599e4d14abcf385c2298f08d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23173-1https://doaj.org/toc/2041-1723Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine performs at least as well as the homologous vaccinations in mice.Alexandra J. SpencerPaul F. McKaySandra Belij-RammerstorferMarta UlaszewskaCameron D. BissettKai HuKarnyart SamnuanAnna K. BlakneyDaniel WrightHannah R. SharpeCiaran GilbrideAdam TrubyElizabeth R. AllenSarah C. GilbertRobin J. ShattockTeresa LambeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandra J. Spencer Paul F. McKay Sandra Belij-Rammerstorfer Marta Ulaszewska Cameron D. Bissett Kai Hu Karnyart Samnuan Anna K. Blakney Daniel Wright Hannah R. Sharpe Ciaran Gilbride Adam Truby Elizabeth R. Allen Sarah C. Gilbert Robin J. Shattock Teresa Lambe Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
description	Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine performs at least as well as the homologous vaccinations in mice.
format	article
author	Alexandra J. Spencer Paul F. McKay Sandra Belij-Rammerstorfer Marta Ulaszewska Cameron D. Bissett Kai Hu Karnyart Samnuan Anna K. Blakney Daniel Wright Hannah R. Sharpe Ciaran Gilbride Adam Truby Elizabeth R. Allen Sarah C. Gilbert Robin J. Shattock Teresa Lambe
author_facet	Alexandra J. Spencer Paul F. McKay Sandra Belij-Rammerstorfer Marta Ulaszewska Cameron D. Bissett Kai Hu Karnyart Samnuan Anna K. Blakney Daniel Wright Hannah R. Sharpe Ciaran Gilbride Adam Truby Elizabeth R. Allen Sarah C. Gilbert Robin J. Shattock Teresa Lambe
author_sort	Alexandra J. Spencer
title	Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
title_short	Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
title_full	Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
title_fullStr	Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
title_full_unstemmed	Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
title_sort	heterologous vaccination regimens with self-amplifying rna and adenoviral covid vaccines induce robust immune responses in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9635c93599e4d14abcf385c2298f08d
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Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

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