IRF3-mediated pathogenicity in a murine model of human hepatitis A.

IRF3-mediated pathogenicity in a murine model of human hepatitis A.

HAV-infected Ifnar1-/- mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling in pathogenesis, but leave unresolved the role o...

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Bibliographic Details
Main Authors: Lu Sun, You Li, Ichiro Misumi, Olga González-López, Lucinda Hensley, John M Cullen, David R McGivern, Mami Matsuda, Ryosuke Suzuki, Ganes C Sen, Asuka Hirai-Yuki, Jason K Whitmire, Stanley M Lemon
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/b97fa5a3c6024389911f79c898d10f9e
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https://doaj.org/article/b97fa5a3c6024389911f79c898d10f9e

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