Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes
Abstract Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein implicated in the pathogenesis of both familial and sporadic Parkinson’s disease (PD), and currently one of the most promising therapeutic targets for drug design in Parkinson’s disease. In contrast, LRRK1, the closest homo...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/b9e5473e709a4a3ca47905077e0c271d |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|