Sirtuins Are Evolutionarily Conserved Viral Restriction Factors

ABSTRACT The seven human sirtuins are a family of ubiquitously expressed and evolutionarily conserved NAD+-dependent deacylases/mono-ADP ribosyltransferases that regulate numerous cellular and organismal functions, including metabolism, cell cycle, and longevity. Here, we report the discovery that a...

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Main Authors: Emre Koyuncu, Hanna G. Budayeva, Yana V. Miteva, Dante P. Ricci, Thomas J. Silhavy, Thomas Shenk, Ileana M. Cristea
Format: article
Language:EN
Published: American Society for Microbiology 2014
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Online Access:https://doaj.org/article/b9ea76d5d00f400d8e2b497edc864f67
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