USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.

Guardado en:
Detalles Bibliográficos
Autores principales: Yunhui Li, Kuntian Luo, Yujiao Yin, Chenming Wu, Min Deng, Lei Li, Yuping Chen, Somaira Nowsheen, Zhenkun Lou, Jian Yuan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/b9ff0e1454eb43a897db3dfb43979b21
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:b9ff0e1454eb43a897db3dfb43979b21
record_format dspace
spelling oai:doaj.org-article:b9ff0e1454eb43a897db3dfb43979b212021-12-02T14:42:22ZUSP13 regulates the RAP80-BRCA1 complex dependent DNA damage response10.1038/ncomms157522041-1723https://doaj.org/article/b9ff0e1454eb43a897db3dfb43979b212017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15752https://doaj.org/toc/2041-1723RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.Yunhui LiKuntian LuoYujiao YinChenming WuMin DengLei LiYuping ChenSomaira NowsheenZhenkun LouJian YuanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yunhui Li
Kuntian Luo
Yujiao Yin
Chenming Wu
Min Deng
Lei Li
Yuping Chen
Somaira Nowsheen
Zhenkun Lou
Jian Yuan
USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
description RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.
format article
author Yunhui Li
Kuntian Luo
Yujiao Yin
Chenming Wu
Min Deng
Lei Li
Yuping Chen
Somaira Nowsheen
Zhenkun Lou
Jian Yuan
author_facet Yunhui Li
Kuntian Luo
Yujiao Yin
Chenming Wu
Min Deng
Lei Li
Yuping Chen
Somaira Nowsheen
Zhenkun Lou
Jian Yuan
author_sort Yunhui Li
title USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
title_short USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
title_full USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
title_fullStr USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
title_full_unstemmed USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
title_sort usp13 regulates the rap80-brca1 complex dependent dna damage response
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b9ff0e1454eb43a897db3dfb43979b21
work_keys_str_mv AT yunhuili usp13regulatestherap80brca1complexdependentdnadamageresponse
AT kuntianluo usp13regulatestherap80brca1complexdependentdnadamageresponse
AT yujiaoyin usp13regulatestherap80brca1complexdependentdnadamageresponse
AT chenmingwu usp13regulatestherap80brca1complexdependentdnadamageresponse
AT mindeng usp13regulatestherap80brca1complexdependentdnadamageresponse
AT leili usp13regulatestherap80brca1complexdependentdnadamageresponse
AT yupingchen usp13regulatestherap80brca1complexdependentdnadamageresponse
AT somairanowsheen usp13regulatestherap80brca1complexdependentdnadamageresponse
AT zhenkunlou usp13regulatestherap80brca1complexdependentdnadamageresponse
AT jianyuan usp13regulatestherap80brca1complexdependentdnadamageresponse
_version_ 1718389712762175488

Ejemplares similares