USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.
Enregistré dans:
Auteurs principaux: | Yunhui Li, Kuntian Luo, Yujiao Yin, Chenming Wu, Min Deng, Lei Li, Yuping Chen, Somaira Nowsheen, Zhenkun Lou, Jian Yuan |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/b9ff0e1454eb43a897db3dfb43979b21 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage
par: Nam Soo Lee, et autres
Publié: (2016) -
ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
par: Somaira Nowsheen, et autres
Publié: (2018) -
ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
par: Wootae Kim, et autres
Publié: (2019) -
CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
par: Tongzheng Liu, et autres
Publié: (2017) -
Structural and functional implication of RAP80 ΔGlu81 mutation.
par: Vikrant, et autres
Publié: (2013)