USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.

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Bibliographic Details
Main Authors: Yunhui Li, Kuntian Luo, Yujiao Yin, Chenming Wu, Min Deng, Lei Li, Yuping Chen, Somaira Nowsheen, Zhenkun Lou, Jian Yuan
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/b9ff0e1454eb43a897db3dfb43979b21
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