Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice

Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice

Involvement of the Toll-like receptor 4 (TLR4) in maladaptive cardiac remodeling and heart failure (HF) upon pressure overload has been studied extensively, but less is known about the role of TLR2. Interplay and redundancy of TLR4 with TLR2 have been reported in other organs but were not investigat...

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Autores principales: Elise L. Kessler, Jiong-Wei Wang, Bart Kok, Maike A. Brans, Angelique Nederlof, Leonie van Stuijvenberg, Chenyuan Huang, Aryan Vink, Fatih Arslan, Igor R. Efimov, Carolyn S. P. Lam, Marc A. Vos, Dominique P. V. de Kleijn, Magda S. C. Fontes, Toon A. B. van Veen
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
toll-like receptors
TLR2
TLR4
heart failure
pressure overload
inflammation
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/ba8d61b686094645bdc5db31469aedd9
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https://doaj.org/article/ba8d61b686094645bdc5db31469aedd9

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