Transketolase regulates sensitivity to APR-246 in p53-null cells independently of oxidative stress modulation
Abstract The prevalence and dire implications of mutations in the tumour suppressor, p53, highlight its appeal as a chemotherapeutic target. We recently showed that impairing cellular antioxidant systems via inhibition of SLC7A11, a component of the system xc − cystine-glutamate antiporter, enhances...
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| Auteurs principaux: | , , , , , |
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| Format: | article |
| Langue: | EN |
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Nature Portfolio
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/ba9b4fb88cd4428c8a2cf11039b060f4 |
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