Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic

Peptide and oligonucleotide systems are known to self-assemble both in nature and artificial systems. Here, the authors combine both forms of self-assembly through the synthesis of peptideoligonucleotide conjugates and show formation of a three-helix structure that dimerises at higher concentrations...

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Autores principales:	Chenguang Lou, Manuel C. Martos-Maldonado, Charlotte S. Madsen, Rasmus P. Thomsen, Søren Roi Midtgaard, Niels Johan Christensen, Jørgen Kjems, Peter W. Thulstrup, Jesper Wengel, Knud J. Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bacb04f814c143a4bbd60f8011d53d2a
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spelling	oai:doaj.org-article:bacb04f814c143a4bbd60f8011d53d2a2021-12-02T15:34:58ZPeptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic10.1038/ncomms122942041-1723https://doaj.org/article/bacb04f814c143a4bbd60f8011d53d2a2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12294https://doaj.org/toc/2041-1723Peptide and oligonucleotide systems are known to self-assemble both in nature and artificial systems. Here, the authors combine both forms of self-assembly through the synthesis of peptideoligonucleotide conjugates and show formation of a three-helix structure that dimerises at higher concentrations.Chenguang LouManuel C. Martos-MaldonadoCharlotte S. MadsenRasmus P. ThomsenSøren Roi MidtgaardNiels Johan ChristensenJørgen KjemsPeter W. ThulstrupJesper WengelKnud J. JensenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chenguang Lou Manuel C. Martos-Maldonado Charlotte S. Madsen Rasmus P. Thomsen Søren Roi Midtgaard Niels Johan Christensen Jørgen Kjems Peter W. Thulstrup Jesper Wengel Knud J. Jensen Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
description	Peptide and oligonucleotide systems are known to self-assemble both in nature and artificial systems. Here, the authors combine both forms of self-assembly through the synthesis of peptideoligonucleotide conjugates and show formation of a three-helix structure that dimerises at higher concentrations.
format	article
author	Chenguang Lou Manuel C. Martos-Maldonado Charlotte S. Madsen Rasmus P. Thomsen Søren Roi Midtgaard Niels Johan Christensen Jørgen Kjems Peter W. Thulstrup Jesper Wengel Knud J. Jensen
author_facet	Chenguang Lou Manuel C. Martos-Maldonado Charlotte S. Madsen Rasmus P. Thomsen Søren Roi Midtgaard Niels Johan Christensen Jørgen Kjems Peter W. Thulstrup Jesper Wengel Knud J. Jensen
author_sort	Chenguang Lou
title	Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
title_short	Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
title_full	Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
title_fullStr	Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
title_full_unstemmed	Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
title_sort	peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bacb04f814c143a4bbd60f8011d53d2a
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Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic

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