Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections

Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections

ABSTRACT Viral pneumonias cause profound worldwide morbidity, necessitating novel strategies to prevent and treat these potentially lethal infections. Stimulation of intrinsic lung defenses via inhalation of synergistically acting Toll-like receptor (TLR) agonists protects mice broadly against pneum...

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Autores principales: Carson T. Kirkpatrick, Yongxing Wang, Miguel M. Leiva Juarez, Pooja Shivshankar, Jezreel Pantaleón García, Alexandria K. Plumer, Vikram V. Kulkarni, Hayden H. Ware, Fahad Gulraiz, Miguel A. Chavez Cavasos, Gabriela Martinez Zayas, Shradha Wali, Andrew P. Rice, Hongbing Liu, James M. Tour, William K. A. Sikkema, Ana S. Cruz Solbes, Keith A. Youker, Michael J. Tuvim, Burton F. Dickey, Scott E. Evans
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
inducible resistance
Toll-like receptors
lung epithelium
mucosal immunity
reactive oxygen species
viral pneumonia
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/bad5b71e30944f789382fafb101c7a34
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https://doaj.org/article/bad5b71e30944f789382fafb101c7a34

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