Validating the concept of mutational signatures with isogenic cell models

As cells evolve towards malignancy, somatic mutations arise from defects in DNA damage and repair processes which are each associated with individual mutation signatures. Here the authors show it is possible to recreate cancer mutational signatures in vitro using gene editing experiments in an isoge...

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Main Authors:	Xueqing Zou, Michel Owusu, Rebecca Harris, Stephen P. Jackson, Joanna I. Loizou, Serena Nik-Zainal
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/bad9605bd33e4fa186fa37e90cab5f13
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id	oai:doaj.org-article:bad9605bd33e4fa186fa37e90cab5f13
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spelling	oai:doaj.org-article:bad9605bd33e4fa186fa37e90cab5f132021-12-02T17:32:34ZValidating the concept of mutational signatures with isogenic cell models10.1038/s41467-018-04052-82041-1723https://doaj.org/article/bad9605bd33e4fa186fa37e90cab5f132018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04052-8https://doaj.org/toc/2041-1723As cells evolve towards malignancy, somatic mutations arise from defects in DNA damage and repair processes which are each associated with individual mutation signatures. Here the authors show it is possible to recreate cancer mutational signatures in vitro using gene editing experiments in an isogenic human-cell system.Xueqing ZouMichel OwusuRebecca HarrisStephen P. JacksonJoanna I. LoizouSerena Nik-ZainalNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xueqing Zou Michel Owusu Rebecca Harris Stephen P. Jackson Joanna I. Loizou Serena Nik-Zainal Validating the concept of mutational signatures with isogenic cell models
description	As cells evolve towards malignancy, somatic mutations arise from defects in DNA damage and repair processes which are each associated with individual mutation signatures. Here the authors show it is possible to recreate cancer mutational signatures in vitro using gene editing experiments in an isogenic human-cell system.
format	article
author	Xueqing Zou Michel Owusu Rebecca Harris Stephen P. Jackson Joanna I. Loizou Serena Nik-Zainal
author_facet	Xueqing Zou Michel Owusu Rebecca Harris Stephen P. Jackson Joanna I. Loizou Serena Nik-Zainal
author_sort	Xueqing Zou
title	Validating the concept of mutational signatures with isogenic cell models
title_short	Validating the concept of mutational signatures with isogenic cell models
title_full	Validating the concept of mutational signatures with isogenic cell models
title_fullStr	Validating the concept of mutational signatures with isogenic cell models
title_full_unstemmed	Validating the concept of mutational signatures with isogenic cell models
title_sort	validating the concept of mutational signatures with isogenic cell models
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bad9605bd33e4fa186fa37e90cab5f13
work_keys_str_mv	AT xueqingzou validatingtheconceptofmutationalsignatureswithisogeniccellmodels AT michelowusu validatingtheconceptofmutationalsignatureswithisogeniccellmodels AT rebeccaharris validatingtheconceptofmutationalsignatureswithisogeniccellmodels AT stephenpjackson validatingtheconceptofmutationalsignatureswithisogeniccellmodels AT joannailoizou validatingtheconceptofmutationalsignatureswithisogeniccellmodels AT serenanikzainal validatingtheconceptofmutationalsignatureswithisogeniccellmodels
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Validating the concept of mutational signatures with isogenic cell models

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