Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis.
In the hypertrophied human heart, fatty acid metabolism is decreased and glucose utilisation is increased. We hypothesized that the sarcolemmal and mitochondrial proteins involved in these key metabolic pathways would mirror these changes, providing a mechanism to account for the modified metabolic...
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Main Authors: | Lisa C Heather, Neil J Howell, Yaso Emmanuel, Mark A Cole, Michael P Frenneaux, Domenico Pagano, Kieran Clarke |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2011
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Online Access: | https://doaj.org/article/baf0ec011cbe4aa2b81c1078baf87b53 |
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