Withaferin A inhibits lymphocyte proliferation, dendritic cell maturation in vitro and prolongs islet allograft survival

Withaferin A inhibits lymphocyte proliferation, dendritic cell maturation in vitro and prolongs islet allograft survival

Abstract The immunosuppressive regimen for clinical allogeneic islet transplantation uses beta cell–toxic compounds such as tacrolimus that cause islet graft loss. Previously we reported that the plant-derived steroidal lactone Withaferin A (WA) can protect islet grafts by inhibiting nuclear factor-...

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Bibliographic Details
Main Authors: Kenjiro Kumano, Mazhar A. Kanak, Prathab Balaji Saravanan, J. P. Blanck, Yang Liu, Srividya Vasu, Michael Lawrence, Bashoo Naziruddin
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/baf64a9defc04421a7f7aa26bc8ec927
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