Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids

A large number of marketed drugs contains a chiral carboxylic acid scaffold. Here, the authors report the asymmetric hydrogenation of α,β-unsaturated carboxylic acids to α-chiral carboxylic acids using a cobalt catalyst bearing an electron-donating chiral diphosphine ligand.

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Autores principales: Xiaoyong Du, Ye Xiao, Jia-Ming Huang, Yao Zhang, Ya-Nan Duan, Heng Wang, Chuan Shi, Gen-Qiang Chen, Xumu Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bb11eceb9a764f89b4c1f436bba6d895
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