Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids

A large number of marketed drugs contains a chiral carboxylic acid scaffold. Here, the authors report the asymmetric hydrogenation of α,β-unsaturated carboxylic acids to α-chiral carboxylic acids using a cobalt catalyst bearing an electron-donating chiral diphosphine ligand.

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Autores principales:	Xiaoyong Du, Ye Xiao, Jia-Ming Huang, Yao Zhang, Ya-Nan Duan, Heng Wang, Chuan Shi, Gen-Qiang Chen, Xumu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb11eceb9a764f89b4c1f436bba6d895
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spelling	oai:doaj.org-article:bb11eceb9a764f89b4c1f436bba6d8952021-12-02T18:02:52ZCobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids10.1038/s41467-020-17057-z2041-1723https://doaj.org/article/bb11eceb9a764f89b4c1f436bba6d8952020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17057-zhttps://doaj.org/toc/2041-1723A large number of marketed drugs contains a chiral carboxylic acid scaffold. Here, the authors report the asymmetric hydrogenation of α,β-unsaturated carboxylic acids to α-chiral carboxylic acids using a cobalt catalyst bearing an electron-donating chiral diphosphine ligand.Xiaoyong DuYe XiaoJia-Ming HuangYao ZhangYa-Nan DuanHeng WangChuan ShiGen-Qiang ChenXumu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyong Du Ye Xiao Jia-Ming Huang Yao Zhang Ya-Nan Duan Heng Wang Chuan Shi Gen-Qiang Chen Xumu Zhang Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
description	A large number of marketed drugs contains a chiral carboxylic acid scaffold. Here, the authors report the asymmetric hydrogenation of α,β-unsaturated carboxylic acids to α-chiral carboxylic acids using a cobalt catalyst bearing an electron-donating chiral diphosphine ligand.
format	article
author	Xiaoyong Du Ye Xiao Jia-Ming Huang Yao Zhang Ya-Nan Duan Heng Wang Chuan Shi Gen-Qiang Chen Xumu Zhang
author_facet	Xiaoyong Du Ye Xiao Jia-Ming Huang Yao Zhang Ya-Nan Duan Heng Wang Chuan Shi Gen-Qiang Chen Xumu Zhang
author_sort	Xiaoyong Du
title	Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
title_short	Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
title_full	Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
title_fullStr	Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
title_full_unstemmed	Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
title_sort	cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bb11eceb9a764f89b4c1f436bba6d895
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Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids

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