In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

To provide in depth characterization of HIV reservoir cells, the authors here develop a single-cell approach to simultaneously sequence TCR, integration sites and proviral genomes, called STIP-Seq, and show that the translation-competent reservoir mainly consists of proviruses with short deletions a...

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Autores principales:	Basiel Cole, Laurens Lambrechts, Pierre Gantner, Ytse Noppe, Noah Bonine, Wojciech Witkowski, Lennie Chen, Sarah Palmer, James I. Mullins, Nicolas Chomont, Marion Pardons, Linos Vandekerckhove
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb2639ad014b4e8797620272ce98b655
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spelling	oai:doaj.org-article:bb2639ad014b4e8797620272ce98b6552021-12-02T16:04:16ZIn-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia10.1038/s41467-021-24080-12041-1723https://doaj.org/article/bb2639ad014b4e8797620272ce98b6552021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24080-1https://doaj.org/toc/2041-1723To provide in depth characterization of HIV reservoir cells, the authors here develop a single-cell approach to simultaneously sequence TCR, integration sites and proviral genomes, called STIP-Seq, and show that the translation-competent reservoir mainly consists of proviruses with short deletions at the 5’-end of the genome.Basiel ColeLaurens LambrechtsPierre GantnerYtse NoppeNoah BonineWojciech WitkowskiLennie ChenSarah PalmerJames I. MullinsNicolas ChomontMarion PardonsLinos VandekerckhoveNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Basiel Cole Laurens Lambrechts Pierre Gantner Ytse Noppe Noah Bonine Wojciech Witkowski Lennie Chen Sarah Palmer James I. Mullins Nicolas Chomont Marion Pardons Linos Vandekerckhove In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia
description	To provide in depth characterization of HIV reservoir cells, the authors here develop a single-cell approach to simultaneously sequence TCR, integration sites and proviral genomes, called STIP-Seq, and show that the translation-competent reservoir mainly consists of proviruses with short deletions at the 5’-end of the genome.
format	article
author	Basiel Cole Laurens Lambrechts Pierre Gantner Ytse Noppe Noah Bonine Wojciech Witkowski Lennie Chen Sarah Palmer James I. Mullins Nicolas Chomont Marion Pardons Linos Vandekerckhove
author_facet	Basiel Cole Laurens Lambrechts Pierre Gantner Ytse Noppe Noah Bonine Wojciech Witkowski Lennie Chen Sarah Palmer James I. Mullins Nicolas Chomont Marion Pardons Linos Vandekerckhove
author_sort	Basiel Cole
title	In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia
title_short	In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia
title_full	In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia
title_fullStr	In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia
title_full_unstemmed	In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia
title_sort	in-depth single-cell analysis of translation-competent hiv-1 reservoirs identifies cellular sources of plasma viremia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb2639ad014b4e8797620272ce98b655
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In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

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