Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A <italic toggle="yes">Streptococcus</italic> Virulence
ABSTRACT Streptolysin O is a potent pore-forming toxin produced by group A Streptococcus. The aims of the present study were to dissect the relative contributions of different structural domains of the protein to hemolytic activity, to obtain a detoxified form of streptolysin O amenable to human vac...
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Main Authors: | , , , , , , , , , , , , , , , , , |
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Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2013
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Subjects: | |
Online Access: | https://doaj.org/article/bb3003ecff814c90b395fe26d22ddb65 |
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