Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A <italic toggle="yes">Streptococcus</italic> Virulence

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Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A <italic toggle="yes">Streptococcus</italic> Virulence

ABSTRACT Streptolysin O is a potent pore-forming toxin produced by group A Streptococcus. The aims of the present study were to dissect the relative contributions of different structural domains of the protein to hemolytic activity, to obtain a detoxified form of streptolysin O amenable to human vac...

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Auteurs principaux:	Emiliano Chiarot, Cristina Faralla, Nico Chiappini, Giovanna Tuscano, Fabiana Falugi, Gabriella Gambellini, Annarita Taddei, Sabrina Capo, Elena Cartocci, Daniele Veggi, Alessia Corrado, Simona Mangiavacchi, Simona Tavarini, Maria Scarselli, Robert Janulczyk, Guido Grandi, Immaculada Margarit, Giuliano Bensi
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2013
Sujets:	Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/bb3003ecff814c90b395fe26d22ddb65
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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