Human NK cell development requires CD56-mediated motility and formation of the developmental synapse

CD56, a splicing variant of NCAM, marks human NK cell differentiation stages. Here the authors show that developing human NK cells form CD56-enriched synapses with stromal cells, and CD56 is critical to promote motility of NK cells that increases with their maturation.

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Autores principales:	Emily M. Mace, Justin T. Gunesch, Amera Dixon, Jordan S. Orange
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb30adb4b9894421b84506abeafc686a
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id	oai:doaj.org-article:bb30adb4b9894421b84506abeafc686a
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spelling	oai:doaj.org-article:bb30adb4b9894421b84506abeafc686a2021-12-02T14:39:11ZHuman NK cell development requires CD56-mediated motility and formation of the developmental synapse10.1038/ncomms121712041-1723https://doaj.org/article/bb30adb4b9894421b84506abeafc686a2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12171https://doaj.org/toc/2041-1723CD56, a splicing variant of NCAM, marks human NK cell differentiation stages. Here the authors show that developing human NK cells form CD56-enriched synapses with stromal cells, and CD56 is critical to promote motility of NK cells that increases with their maturation.Emily M. MaceJustin T. GuneschAmera DixonJordan S. OrangeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily M. Mace Justin T. Gunesch Amera Dixon Jordan S. Orange Human NK cell development requires CD56-mediated motility and formation of the developmental synapse
description	CD56, a splicing variant of NCAM, marks human NK cell differentiation stages. Here the authors show that developing human NK cells form CD56-enriched synapses with stromal cells, and CD56 is critical to promote motility of NK cells that increases with their maturation.
format	article
author	Emily M. Mace Justin T. Gunesch Amera Dixon Jordan S. Orange
author_facet	Emily M. Mace Justin T. Gunesch Amera Dixon Jordan S. Orange
author_sort	Emily M. Mace
title	Human NK cell development requires CD56-mediated motility and formation of the developmental synapse
title_short	Human NK cell development requires CD56-mediated motility and formation of the developmental synapse
title_full	Human NK cell development requires CD56-mediated motility and formation of the developmental synapse
title_fullStr	Human NK cell development requires CD56-mediated motility and formation of the developmental synapse
title_full_unstemmed	Human NK cell development requires CD56-mediated motility and formation of the developmental synapse
title_sort	human nk cell development requires cd56-mediated motility and formation of the developmental synapse
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bb30adb4b9894421b84506abeafc686a
work_keys_str_mv	AT emilymmace humannkcelldevelopmentrequirescd56mediatedmotilityandformationofthedevelopmentalsynapse AT justintgunesch humannkcelldevelopmentrequirescd56mediatedmotilityandformationofthedevelopmentalsynapse AT ameradixon humannkcelldevelopmentrequirescd56mediatedmotilityandformationofthedevelopmentalsynapse AT jordansorange humannkcelldevelopmentrequirescd56mediatedmotilityandformationofthedevelopmentalsynapse
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Human NK cell development requires CD56-mediated motility and formation of the developmental synapse

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