Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

ABSTRACT The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of infected host cells and thereby prompts an inflammatory immune response linked to sepsis. Host guanylate binding proteins (GBPs) promo...

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Autores principales: Ryan Finethy, Sarah Luoma, Nichole Orench-Rivera, Eric M. Feeley, Arun K. Haldar, Masahiro Yamamoto, Thirumala-Devi Kanneganti, Meta J. Kuehn, Jörn Coers
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
GBP2
GBP5
LPS
OMVs
caspase-11
guanylate binding proteins
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/bb4d0719860949808c96af8cd370889b
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https://doaj.org/article/bb4d0719860949808c96af8cd370889b

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