Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)

Abstract Kokumi taste is a well-accepted and characterised taste modality and is described as a sensation of enhancement of sweet, salty, and umami tastes. The Calcium Sensing Receptor (CaSR) has been designated as the putative kokumi taste receptor for humans, and a number of kokumi-active ligands...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. Laffitte, M. Gibbs, C. Hernangomez de Alvaro, J. Addison, Z. N. Lonsdale, M. G. Giribaldi, A. Rossignoli, T. Vennegeerts, M. Winnig, B. Klebansky, J. Skiles, D. W. Logan, S. J. McGrane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bb66a2a9c4fa48c5966d40a7ac48e33e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bb66a2a9c4fa48c5966d40a7ac48e33e
record_format	dspace
spelling	oai:doaj.org-article:bb66a2a9c4fa48c5966d40a7ac48e33e2021-12-02T16:51:31ZKokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)10.1038/s41598-021-89558-w2045-2322https://doaj.org/article/bb66a2a9c4fa48c5966d40a7ac48e33e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89558-whttps://doaj.org/toc/2045-2322Abstract Kokumi taste is a well-accepted and characterised taste modality and is described as a sensation of enhancement of sweet, salty, and umami tastes. The Calcium Sensing Receptor (CaSR) has been designated as the putative kokumi taste receptor for humans, and a number of kokumi-active ligands of CaSR have been discovered recently with activity confirmed both in vivo and in vitro. Domestic cats (Felis catus) are obligate carnivores and accordingly, their diet is abundant in proteins, peptides, and amino acids. We hypothesised that CaSR is a key taste receptor for carnivores, due to its role in the detection of different peptides and amino acids in other species. Using in silico, in vitro and in vivo approaches, here we compare human CaSR to that of a model carnivore, the domestic cat. We found broad similarities in ligand specificity, but differences in taste sensitivity between the two species. Indeed our in vivo data shows that cats are sensitive to CaCl2 as a kokumi compound, but don’t show this same activity with Glutathione, whereas for humans the reverse is true. Collectively, our data suggest that kokumi is an important taste modality for carnivores that drives the palatability of meat-derived compounds such as amino acids and peptides, and that there are differences in the perception of kokumi taste between carnivores and omnivores.A. LaffitteM. GibbsC. Hernangomez de AlvaroJ. AddisonZ. N. LonsdaleM. G. GiribaldiA. RossignoliT. VennegeertsM. WinnigB. KlebanskyJ. SkilesD. W. LoganS. J. McGraneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Laffitte M. Gibbs C. Hernangomez de Alvaro J. Addison Z. N. Lonsdale M. G. Giribaldi A. Rossignoli T. Vennegeerts M. Winnig B. Klebansky J. Skiles D. W. Logan S. J. McGrane Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)
description	Abstract Kokumi taste is a well-accepted and characterised taste modality and is described as a sensation of enhancement of sweet, salty, and umami tastes. The Calcium Sensing Receptor (CaSR) has been designated as the putative kokumi taste receptor for humans, and a number of kokumi-active ligands of CaSR have been discovered recently with activity confirmed both in vivo and in vitro. Domestic cats (Felis catus) are obligate carnivores and accordingly, their diet is abundant in proteins, peptides, and amino acids. We hypothesised that CaSR is a key taste receptor for carnivores, due to its role in the detection of different peptides and amino acids in other species. Using in silico, in vitro and in vivo approaches, here we compare human CaSR to that of a model carnivore, the domestic cat. We found broad similarities in ligand specificity, but differences in taste sensitivity between the two species. Indeed our in vivo data shows that cats are sensitive to CaCl2 as a kokumi compound, but don’t show this same activity with Glutathione, whereas for humans the reverse is true. Collectively, our data suggest that kokumi is an important taste modality for carnivores that drives the palatability of meat-derived compounds such as amino acids and peptides, and that there are differences in the perception of kokumi taste between carnivores and omnivores.
format	article
author	A. Laffitte M. Gibbs C. Hernangomez de Alvaro J. Addison Z. N. Lonsdale M. G. Giribaldi A. Rossignoli T. Vennegeerts M. Winnig B. Klebansky J. Skiles D. W. Logan S. J. McGrane
author_facet	A. Laffitte M. Gibbs C. Hernangomez de Alvaro J. Addison Z. N. Lonsdale M. G. Giribaldi A. Rossignoli T. Vennegeerts M. Winnig B. Klebansky J. Skiles D. W. Logan S. J. McGrane
author_sort	A. Laffitte
title	Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)
title_short	Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)
title_full	Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)
title_fullStr	Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)
title_full_unstemmed	Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)
title_sort	kokumi taste perception is functional in a model carnivore, the domestic cat (felis catus)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bb66a2a9c4fa48c5966d40a7ac48e33e
work_keys_str_mv	AT alaffitte kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT mgibbs kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT chernangomezdealvaro kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT jaddison kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT znlonsdale kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT mggiribaldi kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT arossignoli kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT tvennegeerts kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT mwinnig kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT bklebansky kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT jskiles kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT dwlogan kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus AT sjmcgrane kokumitasteperceptionisfunctionalinamodelcarnivorethedomesticcatfeliscatus
_version_	1718382939945828352

Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus)

Ejemplares similares