Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing

Dsyregulation of mitosis-related alternative splicing in cancer cells is not well understood. Here, the authors show that cancer metastasis-associated antigen 1 (MTA1), an oncogenic chromatin associated protein, is an RNA-binding protein that regulates the alternative splicing and transcript abundan...

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Autores principales:	Jian Liu, Chunxiao Li, Jinsong Wang, Dongkui Xu, Haijuan Wang, Ting Wang, Lina Li, Hui Li, Peng Nan, Jingyao Zhang, Yang Wang, Changzhi Huang, Dong Chen, Yi Zhang, Tao Wen, Qimin Zhan, Fei Ma, Haili Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bb67f8189e5f4ff28d476b2b1f343150
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spelling	oai:doaj.org-article:bb67f8189e5f4ff28d476b2b1f3431502021-12-02T14:55:09ZChromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing10.1038/s41467-020-18259-12041-1723https://doaj.org/article/bb67f8189e5f4ff28d476b2b1f3431502020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18259-1https://doaj.org/toc/2041-1723Dsyregulation of mitosis-related alternative splicing in cancer cells is not well understood. Here, the authors show that cancer metastasis-associated antigen 1 (MTA1), an oncogenic chromatin associated protein, is an RNA-binding protein that regulates the alternative splicing and transcript abundance of mitosis regulators.Jian LiuChunxiao LiJinsong WangDongkui XuHaijuan WangTing WangLina LiHui LiPeng NanJingyao ZhangYang WangChangzhi HuangDong ChenYi ZhangTao WenQimin ZhanFei MaHaili QianNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Liu Chunxiao Li Jinsong Wang Dongkui Xu Haijuan Wang Ting Wang Lina Li Hui Li Peng Nan Jingyao Zhang Yang Wang Changzhi Huang Dong Chen Yi Zhang Tao Wen Qimin Zhan Fei Ma Haili Qian Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
description	Dsyregulation of mitosis-related alternative splicing in cancer cells is not well understood. Here, the authors show that cancer metastasis-associated antigen 1 (MTA1), an oncogenic chromatin associated protein, is an RNA-binding protein that regulates the alternative splicing and transcript abundance of mitosis regulators.
format	article
author	Jian Liu Chunxiao Li Jinsong Wang Dongkui Xu Haijuan Wang Ting Wang Lina Li Hui Li Peng Nan Jingyao Zhang Yang Wang Changzhi Huang Dong Chen Yi Zhang Tao Wen Qimin Zhan Fei Ma Haili Qian
author_facet	Jian Liu Chunxiao Li Jinsong Wang Dongkui Xu Haijuan Wang Ting Wang Lina Li Hui Li Peng Nan Jingyao Zhang Yang Wang Changzhi Huang Dong Chen Yi Zhang Tao Wen Qimin Zhan Fei Ma Haili Qian
author_sort	Jian Liu
title	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_short	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_full	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_fullStr	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_full_unstemmed	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_sort	chromatin modifier mta1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mrna processing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bb67f8189e5f4ff28d476b2b1f343150
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Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing

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