Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing

Dsyregulation of mitosis-related alternative splicing in cancer cells is not well understood. Here, the authors show that cancer metastasis-associated antigen 1 (MTA1), an oncogenic chromatin associated protein, is an RNA-binding protein that regulates the alternative splicing and transcript abundan...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jian Liu, Chunxiao Li, Jinsong Wang, Dongkui Xu, Haijuan Wang, Ting Wang, Lina Li, Hui Li, Peng Nan, Jingyao Zhang, Yang Wang, Changzhi Huang, Dong Chen, Yi Zhang, Tao Wen, Qimin Zhan, Fei Ma, Haili Qian
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/bb67f8189e5f4ff28d476b2b1f343150
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:bb67f8189e5f4ff28d476b2b1f343150
record_format	dspace
spelling	oai:doaj.org-article:bb67f8189e5f4ff28d476b2b1f3431502021-12-02T14:55:09ZChromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing10.1038/s41467-020-18259-12041-1723https://doaj.org/article/bb67f8189e5f4ff28d476b2b1f3431502020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18259-1https://doaj.org/toc/2041-1723Dsyregulation of mitosis-related alternative splicing in cancer cells is not well understood. Here, the authors show that cancer metastasis-associated antigen 1 (MTA1), an oncogenic chromatin associated protein, is an RNA-binding protein that regulates the alternative splicing and transcript abundance of mitosis regulators.Jian LiuChunxiao LiJinsong WangDongkui XuHaijuan WangTing WangLina LiHui LiPeng NanJingyao ZhangYang WangChangzhi HuangDong ChenYi ZhangTao WenQimin ZhanFei MaHaili QianNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Liu Chunxiao Li Jinsong Wang Dongkui Xu Haijuan Wang Ting Wang Lina Li Hui Li Peng Nan Jingyao Zhang Yang Wang Changzhi Huang Dong Chen Yi Zhang Tao Wen Qimin Zhan Fei Ma Haili Qian Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
description	Dsyregulation of mitosis-related alternative splicing in cancer cells is not well understood. Here, the authors show that cancer metastasis-associated antigen 1 (MTA1), an oncogenic chromatin associated protein, is an RNA-binding protein that regulates the alternative splicing and transcript abundance of mitosis regulators.
format	article
author	Jian Liu Chunxiao Li Jinsong Wang Dongkui Xu Haijuan Wang Ting Wang Lina Li Hui Li Peng Nan Jingyao Zhang Yang Wang Changzhi Huang Dong Chen Yi Zhang Tao Wen Qimin Zhan Fei Ma Haili Qian
author_facet	Jian Liu Chunxiao Li Jinsong Wang Dongkui Xu Haijuan Wang Ting Wang Lina Li Hui Li Peng Nan Jingyao Zhang Yang Wang Changzhi Huang Dong Chen Yi Zhang Tao Wen Qimin Zhan Fei Ma Haili Qian
author_sort	Jian Liu
title	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_short	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_full	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_fullStr	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_full_unstemmed	Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing
title_sort	chromatin modifier mta1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mrna processing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bb67f8189e5f4ff28d476b2b1f343150
work_keys_str_mv	AT jianliu chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT chunxiaoli chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT jinsongwang chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT dongkuixu chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT haijuanwang chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT tingwang chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT linali chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT huili chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT pengnan chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT jingyaozhang chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT yangwang chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT changzhihuang chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT dongchen chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT yizhang chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT taowen chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT qiminzhan chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT feima chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing AT hailiqian chromatinmodifiermta1regulatesmitotictransitionandtumorigenesisbyorchestratingmitoticmrnaprocessing
_version_	1718389345744846848

Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing

Similar Items