Exploration of the structural requirements of Aurora Kinase B inhibitors by a combined QSAR, modelling and molecular simulation approach

Abstract Aurora kinase B plays an important role in the cell cycle to orchestrate the mitotic process. The amplification and overexpression of this kinase have been implicated in several human malignancies. Therefore, Aurora kinase B is a potential drug target for anticancer therapies. Here, we comb...

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Auteurs principaux: Sajda Ashraf, Kara E. Ranaghan, Christopher J. Woods, Adrian J. Mulholland, Zaheer Ul-Haq
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/bb75eda4ab704f4381e3015bca49cdde
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