The <italic toggle="yes">Legionella</italic> Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway

The <italic toggle="yes">Legionella</italic> Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway

ABSTRACT Legionella pneumophila, the etiological agent of legionellosis, replicates within phagocytic cells. Crucial to biogenesis of the replicative vacuole is the Dot/Icm type 4 secretion system, which translocates a large number of effectors into the host cell cytosol. Among them is LegK2, a prot...

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Main Authors: Céline Michard, Daniel Sperandio, Nathalie Baïlo, Javier Pizarro-Cerdá, Lawrence LeClaire, Elise Chadeau-Argaud, Isabel Pombo-Grégoire, Eva Hervet, Anne Vianney, Christophe Gilbert, Mathias Faure, Pascale Cossart, Patricia Doublet
Format: article
Language:EN
Published: American Society for Microbiology 2015
Subjects:
Microbiology
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Online Access:https://doaj.org/article/bb8e325a0ac64bde809d599e2d6549bb
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https://doaj.org/article/bb8e325a0ac64bde809d599e2d6549bb

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