Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures.

Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures.

Environmental exposure to manganese (Mn) leads to a neurodegenerative disease that has shared clinical characteristics with Parkinson's disease (PD). Mn-induced neurotoxicity is time- and dose-dependent, due in part to oxidative stress. We ascertained the molecular targets involved in Mn-induce...

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Autores principales: Vernat Exil, Li Ping, Yingchun Yu, Sudipta Chakraborty, Samuel W Caito, K Sam Wells, Pratap Karki, Eunsook Lee, Michael Aschner
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/bba6e2a186de4cc785a041da88e5a646
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