Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity

Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity

Sepsis due to multidrug resistant pathogens is the most common cause of death in intensive care units. Here, the authors report that fecal microbiota transplant (FMT) can rescue mice from lethal sepsis of pathogens isolated from stool of a critically ill patient and show that FMT reverses the immuno...

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Autores principales: Sangman M. Kim, Jennifer R. DeFazio, Sanjiv K. Hyoju, Kishan Sangani, Robert Keskey, Monika A. Krezalek, Nikolai N. Khodarev, Naseer Sangwan, Scott Christley, Katharine G. Harris, Ankit Malik, Alexander Zaborin, Romain Bouziat, Diana R. Ranoa, Mara Wiegerinck, Jordan D. Ernest, Baddr A. Shakhsheer, Irma D. Fleming, Ralph R. Weichselbaum, Dionysios A. Antonopoulos, Jack A. Gilbert, Luis B. Barreiro, Olga Zaborina, Bana Jabri, John C. Alverdy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bbaea16a322d4b3d8f09bd8859a8e5d8
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spelling oai:doaj.org-article:bbaea16a322d4b3d8f09bd8859a8e5d82021-12-02T14:35:46ZFecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity10.1038/s41467-020-15545-w2041-1723https://doaj.org/article/bbaea16a322d4b3d8f09bd8859a8e5d82020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15545-whttps://doaj.org/toc/2041-1723Sepsis due to multidrug resistant pathogens is the most common cause of death in intensive care units. Here, the authors report that fecal microbiota transplant (FMT) can rescue mice from lethal sepsis of pathogens isolated from stool of a critically ill patient and show that FMT reverses the immunosuppressive effect induced by the pathogen community.Sangman M. KimJennifer R. DeFazioSanjiv K. HyojuKishan SanganiRobert KeskeyMonika A. KrezalekNikolai N. KhodarevNaseer SangwanScott ChristleyKatharine G. HarrisAnkit MalikAlexander ZaborinRomain BouziatDiana R. RanoaMara WiegerinckJordan D. ErnestBaddr A. ShakhsheerIrma D. FlemingRalph R. WeichselbaumDionysios A. AntonopoulosJack A. GilbertLuis B. BarreiroOlga ZaborinaBana JabriJohn C. AlverdyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sangman M. Kim
Jennifer R. DeFazio
Sanjiv K. Hyoju
Kishan Sangani
Robert Keskey
Monika A. Krezalek
Nikolai N. Khodarev
Naseer Sangwan
Scott Christley
Katharine G. Harris
Ankit Malik
Alexander Zaborin
Romain Bouziat
Diana R. Ranoa
Mara Wiegerinck
Jordan D. Ernest
Baddr A. Shakhsheer
Irma D. Fleming
Ralph R. Weichselbaum
Dionysios A. Antonopoulos
Jack A. Gilbert
Luis B. Barreiro
Olga Zaborina
Bana Jabri
John C. Alverdy
Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
description Sepsis due to multidrug resistant pathogens is the most common cause of death in intensive care units. Here, the authors report that fecal microbiota transplant (FMT) can rescue mice from lethal sepsis of pathogens isolated from stool of a critically ill patient and show that FMT reverses the immunosuppressive effect induced by the pathogen community.
format article
author Sangman M. Kim
Jennifer R. DeFazio
Sanjiv K. Hyoju
Kishan Sangani
Robert Keskey
Monika A. Krezalek
Nikolai N. Khodarev
Naseer Sangwan
Scott Christley
Katharine G. Harris
Ankit Malik
Alexander Zaborin
Romain Bouziat
Diana R. Ranoa
Mara Wiegerinck
Jordan D. Ernest
Baddr A. Shakhsheer
Irma D. Fleming
Ralph R. Weichselbaum
Dionysios A. Antonopoulos
Jack A. Gilbert
Luis B. Barreiro
Olga Zaborina
Bana Jabri
John C. Alverdy
author_facet Sangman M. Kim
Jennifer R. DeFazio
Sanjiv K. Hyoju
Kishan Sangani
Robert Keskey
Monika A. Krezalek
Nikolai N. Khodarev
Naseer Sangwan
Scott Christley
Katharine G. Harris
Ankit Malik
Alexander Zaborin
Romain Bouziat
Diana R. Ranoa
Mara Wiegerinck
Jordan D. Ernest
Baddr A. Shakhsheer
Irma D. Fleming
Ralph R. Weichselbaum
Dionysios A. Antonopoulos
Jack A. Gilbert
Luis B. Barreiro
Olga Zaborina
Bana Jabri
John C. Alverdy
author_sort Sangman M. Kim
title Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
title_short Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
title_full Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
title_fullStr Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
title_full_unstemmed Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
title_sort fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/bbaea16a322d4b3d8f09bd8859a8e5d8
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