Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B.

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B.

<h4>Background</h4>We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent manner.<h4>Methodology/principal findings</h4>Optical imaging of uptake kinetics...

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Autores principales: Mathias Gehrmann, Stefan Stangl, Andreas Kirschner, Gemma A Foulds, Wolfgang Sievert, Brigitte T Doss, Axel Walch, Alan G Pockley, Gabriele Multhoff
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/bbe5931322b0429783f0f82fe2648265
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