Acetylation of C/EBPα inhibits its granulopoietic function

Acetylation of C/EBPα inhibits its granulopoietic function

C/EBPα is an essential transcription factor for myeloid lineage commitment. Here, the authors show that acetylation of C/EBPα at K298 and K302, mediated at least in part by GCN5, impairs C/EBPα DNA binding ability and modulates C/EBPα transcriptional activity.

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Bibliographic Details
Main Authors: Deepak Bararia, Hui Si Kwok, Robert S. Welner, Akihiko Numata, Menyhárt B. Sárosi, Henry Yang, Sheena Wee, Sebastian Tschuri, Debleena Ray, Oliver Weigert, Elena Levantini, Alexander K. Ebralidze, Jayantha Gunaratne, Daniel G. Tenen
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/bbfd33738c434d31b7e3a3a8aebe9853
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Internet

https://doaj.org/article/bbfd33738c434d31b7e3a3a8aebe9853

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