Acetylation of C/EBPα inhibits its granulopoietic function

Acetylation of C/EBPα inhibits its granulopoietic function

C/EBPα is an essential transcription factor for myeloid lineage commitment. Here, the authors show that acetylation of C/EBPα at K298 and K302, mediated at least in part by GCN5, impairs C/EBPα DNA binding ability and modulates C/EBPα transcriptional activity.

Guardado en:
Detalles Bibliográficos
Autores principales: Deepak Bararia, Hui Si Kwok, Robert S. Welner, Akihiko Numata, Menyhárt B. Sárosi, Henry Yang, Sheena Wee, Sebastian Tschuri, Debleena Ray, Oliver Weigert, Elena Levantini, Alexander K. Ebralidze, Jayantha Gunaratne, Daniel G. Tenen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/bbfd33738c434d31b7e3a3a8aebe9853
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:C/EBPα is an essential transcription factor for myeloid lineage commitment. Here, the authors show that acetylation of C/EBPα at K298 and K302, mediated at least in part by GCN5, impairs C/EBPα DNA binding ability and modulates C/EBPα transcriptional activity.

Ejemplares similares