Acetylation of C/EBPα inhibits its granulopoietic function
C/EBPα is an essential transcription factor for myeloid lineage commitment. Here, the authors show that acetylation of C/EBPα at K298 and K302, mediated at least in part by GCN5, impairs C/EBPα DNA binding ability and modulates C/EBPα transcriptional activity.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/bbfd33738c434d31b7e3a3a8aebe9853 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:bbfd33738c434d31b7e3a3a8aebe9853 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:bbfd33738c434d31b7e3a3a8aebe98532021-12-02T15:34:09ZAcetylation of C/EBPα inhibits its granulopoietic function10.1038/ncomms109682041-1723https://doaj.org/article/bbfd33738c434d31b7e3a3a8aebe98532016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10968https://doaj.org/toc/2041-1723C/EBPα is an essential transcription factor for myeloid lineage commitment. Here, the authors show that acetylation of C/EBPα at K298 and K302, mediated at least in part by GCN5, impairs C/EBPα DNA binding ability and modulates C/EBPα transcriptional activity.Deepak BarariaHui Si KwokRobert S. WelnerAkihiko NumataMenyhárt B. SárosiHenry YangSheena WeeSebastian TschuriDebleena RayOliver WeigertElena LevantiniAlexander K. EbralidzeJayantha GunaratneDaniel G. TenenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Deepak Bararia Hui Si Kwok Robert S. Welner Akihiko Numata Menyhárt B. Sárosi Henry Yang Sheena Wee Sebastian Tschuri Debleena Ray Oliver Weigert Elena Levantini Alexander K. Ebralidze Jayantha Gunaratne Daniel G. Tenen Acetylation of C/EBPα inhibits its granulopoietic function |
| description |
C/EBPα is an essential transcription factor for myeloid lineage commitment. Here, the authors show that acetylation of C/EBPα at K298 and K302, mediated at least in part by GCN5, impairs C/EBPα DNA binding ability and modulates C/EBPα transcriptional activity. |
| format |
article |
| author |
Deepak Bararia Hui Si Kwok Robert S. Welner Akihiko Numata Menyhárt B. Sárosi Henry Yang Sheena Wee Sebastian Tschuri Debleena Ray Oliver Weigert Elena Levantini Alexander K. Ebralidze Jayantha Gunaratne Daniel G. Tenen |
| author_facet |
Deepak Bararia Hui Si Kwok Robert S. Welner Akihiko Numata Menyhárt B. Sárosi Henry Yang Sheena Wee Sebastian Tschuri Debleena Ray Oliver Weigert Elena Levantini Alexander K. Ebralidze Jayantha Gunaratne Daniel G. Tenen |
| author_sort |
Deepak Bararia |
| title |
Acetylation of C/EBPα inhibits its granulopoietic function |
| title_short |
Acetylation of C/EBPα inhibits its granulopoietic function |
| title_full |
Acetylation of C/EBPα inhibits its granulopoietic function |
| title_fullStr |
Acetylation of C/EBPα inhibits its granulopoietic function |
| title_full_unstemmed |
Acetylation of C/EBPα inhibits its granulopoietic function |
| title_sort |
acetylation of c/ebpα inhibits its granulopoietic function |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/bbfd33738c434d31b7e3a3a8aebe9853 |
| work_keys_str_mv |
AT deepakbararia acetylationofcebpainhibitsitsgranulopoieticfunction AT huisikwok acetylationofcebpainhibitsitsgranulopoieticfunction AT robertswelner acetylationofcebpainhibitsitsgranulopoieticfunction AT akihikonumata acetylationofcebpainhibitsitsgranulopoieticfunction AT menyhartbsarosi acetylationofcebpainhibitsitsgranulopoieticfunction AT henryyang acetylationofcebpainhibitsitsgranulopoieticfunction AT sheenawee acetylationofcebpainhibitsitsgranulopoieticfunction AT sebastiantschuri acetylationofcebpainhibitsitsgranulopoieticfunction AT debleenaray acetylationofcebpainhibitsitsgranulopoieticfunction AT oliverweigert acetylationofcebpainhibitsitsgranulopoieticfunction AT elenalevantini acetylationofcebpainhibitsitsgranulopoieticfunction AT alexanderkebralidze acetylationofcebpainhibitsitsgranulopoieticfunction AT jayanthagunaratne acetylationofcebpainhibitsitsgranulopoieticfunction AT danielgtenen acetylationofcebpainhibitsitsgranulopoieticfunction |
| _version_ |
1718386925482541056 |