Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes

Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes

Cycloisomerization of 1,n-allenynes allows to efficiently assembly polycyclic skeletons, however its asymmetric variant remains elusive. Here, the authors report the enantioselective Rh(I)-catalyzed cycloisomerization of 1,6-allenynes and disclose an uncommon 5-exo-dig pathway via DFT calculations.

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Autores principales: Xu Deng, Li-Yang Shi, Jialing Lan, Yu-Qing Guan, Xiaoyong Zhang, Hui Lv, Lung Wa Chung, Xumu Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/bc0669dbae4241898be7d375a32d825b
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https://doaj.org/article/bc0669dbae4241898be7d375a32d825b

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