Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes

Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes

Cycloisomerization of 1,n-allenynes allows to efficiently assembly polycyclic skeletons, however its asymmetric variant remains elusive. Here, the authors report the enantioselective Rh(I)-catalyzed cycloisomerization of 1,6-allenynes and disclose an uncommon 5-exo-dig pathway via DFT calculations.

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Autores principales: Xu Deng, Li-Yang Shi, Jialing Lan, Yu-Qing Guan, Xiaoyong Zhang, Hui Lv, Lung Wa Chung, Xumu Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/bc0669dbae4241898be7d375a32d825b
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spelling oai:doaj.org-article:bc0669dbae4241898be7d375a32d825b2021-12-02T17:32:55ZEnantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes10.1038/s41467-019-08900-z2041-1723https://doaj.org/article/bc0669dbae4241898be7d375a32d825b2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08900-zhttps://doaj.org/toc/2041-1723Cycloisomerization of 1,n-allenynes allows to efficiently assembly polycyclic skeletons, however its asymmetric variant remains elusive. Here, the authors report the enantioselective Rh(I)-catalyzed cycloisomerization of 1,6-allenynes and disclose an uncommon 5-exo-dig pathway via DFT calculations.Xu DengLi-Yang ShiJialing LanYu-Qing GuanXiaoyong ZhangHui LvLung Wa ChungXumu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xu Deng
Li-Yang Shi
Jialing Lan
Yu-Qing Guan
Xiaoyong Zhang
Hui Lv
Lung Wa Chung
Xumu Zhang
Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes
description Cycloisomerization of 1,n-allenynes allows to efficiently assembly polycyclic skeletons, however its asymmetric variant remains elusive. Here, the authors report the enantioselective Rh(I)-catalyzed cycloisomerization of 1,6-allenynes and disclose an uncommon 5-exo-dig pathway via DFT calculations.
format article
author Xu Deng
Li-Yang Shi
Jialing Lan
Yu-Qing Guan
Xiaoyong Zhang
Hui Lv
Lung Wa Chung
Xumu Zhang
author_facet Xu Deng
Li-Yang Shi
Jialing Lan
Yu-Qing Guan
Xiaoyong Zhang
Hui Lv
Lung Wa Chung
Xumu Zhang
author_sort Xu Deng
title Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes
title_short Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes
title_full Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes
title_fullStr Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes
title_full_unstemmed Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes
title_sort enantioselective rhodium-catalyzed cycloisomerization of 1,6-allenynes to access 5/6-fused bicycle[4.3.0]nonadienes
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/bc0669dbae4241898be7d375a32d825b
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AT liyangshi enantioselectiverhodiumcatalyzedcycloisomerizationof16allenynestoaccess56fusedbicycle430nonadienes
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