Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting

RNA polymerase I (Pol I) catalyses the transcription of ribosomal RNA precursors, and its transcription initiation mechanism differs from that of Pol II and Pol III. Here the authors present the cryo-EM structure of a trapped early intermediate stage of promoter-recruited Pol I, which reveals the in...

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Autores principales:	Michael Pilsl, Christoph Engel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc12969f6f034529abea1788d34ac181
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id	oai:doaj.org-article:bc12969f6f034529abea1788d34ac181
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spelling	oai:doaj.org-article:bc12969f6f034529abea1788d34ac1812021-12-02T16:56:50ZStructural basis of RNA polymerase I pre-initiation complex formation and promoter melting10.1038/s41467-020-15052-y2041-1723https://doaj.org/article/bc12969f6f034529abea1788d34ac1812020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15052-yhttps://doaj.org/toc/2041-1723RNA polymerase I (Pol I) catalyses the transcription of ribosomal RNA precursors, and its transcription initiation mechanism differs from that of Pol II and Pol III. Here the authors present the cryo-EM structure of a trapped early intermediate stage of promoter-recruited Pol I, which reveals the interactions of the basal rDNA transcription machinery with the native promoter, and discuss the mechanistic implications.Michael PilslChristoph EngelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Pilsl Christoph Engel Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting
description	RNA polymerase I (Pol I) catalyses the transcription of ribosomal RNA precursors, and its transcription initiation mechanism differs from that of Pol II and Pol III. Here the authors present the cryo-EM structure of a trapped early intermediate stage of promoter-recruited Pol I, which reveals the interactions of the basal rDNA transcription machinery with the native promoter, and discuss the mechanistic implications.
format	article
author	Michael Pilsl Christoph Engel
author_facet	Michael Pilsl Christoph Engel
author_sort	Michael Pilsl
title	Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting
title_short	Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting
title_full	Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting
title_fullStr	Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting
title_full_unstemmed	Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting
title_sort	structural basis of rna polymerase i pre-initiation complex formation and promoter melting
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bc12969f6f034529abea1788d34ac181
work_keys_str_mv	AT michaelpilsl structuralbasisofrnapolymeraseipreinitiationcomplexformationandpromotermelting AT christophengel structuralbasisofrnapolymeraseipreinitiationcomplexformationandpromotermelting
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Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting

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