FAM13A affects body fat distribution and adipocyte function
Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits.
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Nature Portfolio
2020
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oai:doaj.org-article:bc1db2e1724a4f73a77947050955442a2021-12-02T17:31:07ZFAM13A affects body fat distribution and adipocyte function10.1038/s41467-020-15291-z2041-1723https://doaj.org/article/bc1db2e1724a4f73a77947050955442a2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15291-zhttps://doaj.org/toc/2041-1723Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits.Mohsen FathzadehJiehan LiAbhiram RaoNaomi CookIndumathi ChennamsettyMarcus SeldinXiang ZhouPanjamaporn SangwungMichael J. GloudemansMark KellerAllan AttieJing YangMartin WabitschIvan Carcamo-OriveYuko TadaAldons J. LusisMyung Kyun ShinCliona M. MolonyTracey McLaughlinGerald ReavenStephen B. MontgomeryDermot ReillyThomas QuertermousErik IngelssonJoshua W. KnowlesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mohsen Fathzadeh Jiehan Li Abhiram Rao Naomi Cook Indumathi Chennamsetty Marcus Seldin Xiang Zhou Panjamaporn Sangwung Michael J. Gloudemans Mark Keller Allan Attie Jing Yang Martin Wabitsch Ivan Carcamo-Orive Yuko Tada Aldons J. Lusis Myung Kyun Shin Cliona M. Molony Tracey McLaughlin Gerald Reaven Stephen B. Montgomery Dermot Reilly Thomas Quertermous Erik Ingelsson Joshua W. Knowles FAM13A affects body fat distribution and adipocyte function |
| description |
Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits. |
| format |
article |
| author |
Mohsen Fathzadeh Jiehan Li Abhiram Rao Naomi Cook Indumathi Chennamsetty Marcus Seldin Xiang Zhou Panjamaporn Sangwung Michael J. Gloudemans Mark Keller Allan Attie Jing Yang Martin Wabitsch Ivan Carcamo-Orive Yuko Tada Aldons J. Lusis Myung Kyun Shin Cliona M. Molony Tracey McLaughlin Gerald Reaven Stephen B. Montgomery Dermot Reilly Thomas Quertermous Erik Ingelsson Joshua W. Knowles |
| author_facet |
Mohsen Fathzadeh Jiehan Li Abhiram Rao Naomi Cook Indumathi Chennamsetty Marcus Seldin Xiang Zhou Panjamaporn Sangwung Michael J. Gloudemans Mark Keller Allan Attie Jing Yang Martin Wabitsch Ivan Carcamo-Orive Yuko Tada Aldons J. Lusis Myung Kyun Shin Cliona M. Molony Tracey McLaughlin Gerald Reaven Stephen B. Montgomery Dermot Reilly Thomas Quertermous Erik Ingelsson Joshua W. Knowles |
| author_sort |
Mohsen Fathzadeh |
| title |
FAM13A affects body fat distribution and adipocyte function |
| title_short |
FAM13A affects body fat distribution and adipocyte function |
| title_full |
FAM13A affects body fat distribution and adipocyte function |
| title_fullStr |
FAM13A affects body fat distribution and adipocyte function |
| title_full_unstemmed |
FAM13A affects body fat distribution and adipocyte function |
| title_sort |
fam13a affects body fat distribution and adipocyte function |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/bc1db2e1724a4f73a77947050955442a |
| work_keys_str_mv |
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