Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

The emergence and spread of artemisinin resistance has compromised antimalarial efficacy. Here, Mok et al. apply quantitative transcriptomics, proteomics, and metabolomics to provide evidence that K13 mutations alter multiple aspects of the parasite’s intra-erythrocytic development to enhance surviv...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sachel Mok, Barbara H. Stokes, Nina F. Gnädig, Leila S. Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R. Bottrill, Jaishree Tripathi, Rick M. Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B. Tobin, David A. Fidock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc2f468af6fd4c64bd1c2706fa3f4ce6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc2f468af6fd4c64bd1c2706fa3f4ce6
record_format	dspace
spelling	oai:doaj.org-article:bc2f468af6fd4c64bd1c2706fa3f4ce62021-12-02T13:51:03ZArtemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival10.1038/s41467-020-20805-w2041-1723https://doaj.org/article/bc2f468af6fd4c64bd1c2706fa3f4ce62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20805-whttps://doaj.org/toc/2041-1723The emergence and spread of artemisinin resistance has compromised antimalarial efficacy. Here, Mok et al. apply quantitative transcriptomics, proteomics, and metabolomics to provide evidence that K13 mutations alter multiple aspects of the parasite’s intra-erythrocytic development to enhance survival following artemisinin treatment.Sachel MokBarbara H. StokesNina F. GnädigLeila S. RossTomas YeoChanaki AmaratungaErik AllmanLev SolyakovAndrew R. BottrillJaishree TripathiRick M. FairhurstManuel LlinásZbynek BozdechAndrew B. TobinDavid A. FidockNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sachel Mok Barbara H. Stokes Nina F. Gnädig Leila S. Ross Tomas Yeo Chanaki Amaratunga Erik Allman Lev Solyakov Andrew R. Bottrill Jaishree Tripathi Rick M. Fairhurst Manuel Llinás Zbynek Bozdech Andrew B. Tobin David A. Fidock Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
description	The emergence and spread of artemisinin resistance has compromised antimalarial efficacy. Here, Mok et al. apply quantitative transcriptomics, proteomics, and metabolomics to provide evidence that K13 mutations alter multiple aspects of the parasite’s intra-erythrocytic development to enhance survival following artemisinin treatment.
format	article
author	Sachel Mok Barbara H. Stokes Nina F. Gnädig Leila S. Ross Tomas Yeo Chanaki Amaratunga Erik Allman Lev Solyakov Andrew R. Bottrill Jaishree Tripathi Rick M. Fairhurst Manuel Llinás Zbynek Bozdech Andrew B. Tobin David A. Fidock
author_facet	Sachel Mok Barbara H. Stokes Nina F. Gnädig Leila S. Ross Tomas Yeo Chanaki Amaratunga Erik Allman Lev Solyakov Andrew R. Bottrill Jaishree Tripathi Rick M. Fairhurst Manuel Llinás Zbynek Bozdech Andrew B. Tobin David A. Fidock
author_sort	Sachel Mok
title	Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
title_short	Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
title_full	Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
title_fullStr	Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
title_full_unstemmed	Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
title_sort	artemisinin-resistant k13 mutations rewire plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc2f468af6fd4c64bd1c2706fa3f4ce6
work_keys_str_mv	AT sachelmok artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT barbarahstokes artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT ninafgnadig artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT leilasross artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT tomasyeo artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT chanakiamaratunga artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT erikallman artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT levsolyakov artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT andrewrbottrill artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT jaishreetripathi artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT rickmfairhurst artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT manuelllinas artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT zbynekbozdech artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT andrewbtobin artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival AT davidafidock artemisininresistantk13mutationsrewireplasmodiumfalciparumsintraerythrocyticmetabolicprogramtoenhancesurvival
_version_	1718392461786611712

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

Ejemplares similares