NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Though endocytosed dietary cholesterol is transferred to the endoplasmic reticulum (ER), how this is regulated is unclear. Here, the authors report a role for Niemann-Pick Type C Protein 1 (NPC1) in tethering endocytic organelles to the ER, which may contribute to interorganelle cholesterol transpor...

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Auteurs principaux: D. Höglinger, T. Burgoyne, E. Sanchez-Heras, P. Hartwig, A. Colaco, J. Newton, C. E. Futter, S. Spiegel, F. M. Platt, E. R Eden
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/bc32153db7a043bb84da6f32cb302ba6
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