NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Though endocytosed dietary cholesterol is transferred to the endoplasmic reticulum (ER), how this is regulated is unclear. Here, the authors report a role for Niemann-Pick Type C Protein 1 (NPC1) in tethering endocytic organelles to the ER, which may contribute to interorganelle cholesterol transpor...

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Autores principales: D. Höglinger, T. Burgoyne, E. Sanchez-Heras, P. Hartwig, A. Colaco, J. Newton, C. E. Futter, S. Spiegel, F. M. Platt, E. R Eden
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/bc32153db7a043bb84da6f32cb302ba6
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