NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Though endocytosed dietary cholesterol is transferred to the endoplasmic reticulum (ER), how this is regulated is unclear. Here, the authors report a role for Niemann-Pick Type C Protein 1 (NPC1) in tethering endocytic organelles to the ER, which may contribute to interorganelle cholesterol transpor...

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Autores principales:	D. Höglinger, T. Burgoyne, E. Sanchez-Heras, P. Hartwig, A. Colaco, J. Newton, C. E. Futter, S. Spiegel, F. M. Platt, E. R Eden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc32153db7a043bb84da6f32cb302ba6
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spelling	oai:doaj.org-article:bc32153db7a043bb84da6f32cb302ba62021-12-02T14:39:57ZNPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress10.1038/s41467-019-12152-22041-1723https://doaj.org/article/bc32153db7a043bb84da6f32cb302ba62019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12152-2https://doaj.org/toc/2041-1723Though endocytosed dietary cholesterol is transferred to the endoplasmic reticulum (ER), how this is regulated is unclear. Here, the authors report a role for Niemann-Pick Type C Protein 1 (NPC1) in tethering endocytic organelles to the ER, which may contribute to interorganelle cholesterol transport.D. HöglingerT. BurgoyneE. Sanchez-HerasP. HartwigA. ColacoJ. NewtonC. E. FutterS. SpiegelF. M. PlattE. R EdenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q D. Höglinger T. Burgoyne E. Sanchez-Heras P. Hartwig A. Colaco J. Newton C. E. Futter S. Spiegel F. M. Platt E. R Eden NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
description	Though endocytosed dietary cholesterol is transferred to the endoplasmic reticulum (ER), how this is regulated is unclear. Here, the authors report a role for Niemann-Pick Type C Protein 1 (NPC1) in tethering endocytic organelles to the ER, which may contribute to interorganelle cholesterol transport.
format	article
author	D. Höglinger T. Burgoyne E. Sanchez-Heras P. Hartwig A. Colaco J. Newton C. E. Futter S. Spiegel F. M. Platt E. R Eden
author_facet	D. Höglinger T. Burgoyne E. Sanchez-Heras P. Hartwig A. Colaco J. Newton C. E. Futter S. Spiegel F. M. Platt E. R Eden
author_sort	D. Höglinger
title	NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
title_short	NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
title_full	NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
title_fullStr	NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
title_full_unstemmed	NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
title_sort	npc1 regulates er contacts with endocytic organelles to mediate cholesterol egress
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bc32153db7a043bb84da6f32cb302ba6
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NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

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