Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Abstract Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been reported to promote chronic inflamm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eleonora Ciarlo, Tytti Heinonen, Jérôme Lugrin, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc479b495c564277aaaa4232ca0847e2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc479b495c564277aaaa4232ca0847e2
record_format	dspace
spelling	oai:doaj.org-article:bc479b495c564277aaaa4232ca0847e22021-12-02T16:05:59ZSirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections10.1038/s41598-017-04263-x2045-2322https://doaj.org/article/bc479b495c564277aaaa4232ca0847e22017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04263-xhttps://doaj.org/toc/2045-2322Abstract Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been reported to promote chronic inflammation-related disorders, but whether SIRT3 impacts on innate immune responses and host defenses against infections remains essentially unknown. This aspect is of primary importance considering the great interest in developing SIRT3-targeted therapies. Using SIRT3 knockout mice, we show that SIRT3 deficiency does not affect immune cell development and microbial ligand-induced proliferation and cytokine production by splenocytes, macrophages and dendritic cells. Going well along with these observations, SIRT3 deficiency has no major impact on cytokine production, bacterial burden and survival of mice subjected to endotoxemia, Escherichia coli peritonitis, Klebsiella pneumoniae pneumonia, listeriosis and candidiasis of diverse severity. These data suggest that SIRT3 is not critical to fight infections and support the safety of SIRT3-directed therapies based on SIRT3 activators or inhibitors for treating metabolic, oncologic and neurodegenerative diseases without putting patients at risk of infection.Eleonora CiarloTytti HeinonenJérôme LugrinHans Acha-OrbeaDidier Le RoyJohan AuwerxThierry RogerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eleonora Ciarlo Tytti Heinonen Jérôme Lugrin Hans Acha-Orbea Didier Le Roy Johan Auwerx Thierry Roger Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
description	Abstract Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been reported to promote chronic inflammation-related disorders, but whether SIRT3 impacts on innate immune responses and host defenses against infections remains essentially unknown. This aspect is of primary importance considering the great interest in developing SIRT3-targeted therapies. Using SIRT3 knockout mice, we show that SIRT3 deficiency does not affect immune cell development and microbial ligand-induced proliferation and cytokine production by splenocytes, macrophages and dendritic cells. Going well along with these observations, SIRT3 deficiency has no major impact on cytokine production, bacterial burden and survival of mice subjected to endotoxemia, Escherichia coli peritonitis, Klebsiella pneumoniae pneumonia, listeriosis and candidiasis of diverse severity. These data suggest that SIRT3 is not critical to fight infections and support the safety of SIRT3-directed therapies based on SIRT3 activators or inhibitors for treating metabolic, oncologic and neurodegenerative diseases without putting patients at risk of infection.
format	article
author	Eleonora Ciarlo Tytti Heinonen Jérôme Lugrin Hans Acha-Orbea Didier Le Roy Johan Auwerx Thierry Roger
author_facet	Eleonora Ciarlo Tytti Heinonen Jérôme Lugrin Hans Acha-Orbea Didier Le Roy Johan Auwerx Thierry Roger
author_sort	Eleonora Ciarlo
title	Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
title_short	Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
title_full	Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
title_fullStr	Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
title_full_unstemmed	Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
title_sort	sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bc479b495c564277aaaa4232ca0847e2
work_keys_str_mv	AT eleonoraciarlo sirtuin3deficiencydoesnotalterhostdefensesagainstbacterialandfungalinfections AT tyttiheinonen sirtuin3deficiencydoesnotalterhostdefensesagainstbacterialandfungalinfections AT jeromelugrin sirtuin3deficiencydoesnotalterhostdefensesagainstbacterialandfungalinfections AT hansachaorbea sirtuin3deficiencydoesnotalterhostdefensesagainstbacterialandfungalinfections AT didierleroy sirtuin3deficiencydoesnotalterhostdefensesagainstbacterialandfungalinfections AT johanauwerx sirtuin3deficiencydoesnotalterhostdefensesagainstbacterialandfungalinfections AT thierryroger sirtuin3deficiencydoesnotalterhostdefensesagainstbacterialandfungalinfections
_version_	1718385172811874304

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Ejemplares similares