Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis

Idiopathic scoliosis is a disorder of unknown etiology. Bone biopsies from idiopathic scoliosis patients revealed changes at cellular and molecular level. Osteocytic sclerostin is downregulated, and serum level of sclerostin is decreased. Osteocytes in idiopathic scoliosis appear to be less active w...

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Autores principales:	Elias S. Vasiliadis, Dimitrios Stergios Evangelopoulos, Angelos Kaspiris, Christos Vlachos, Spyros G. Pneumaticos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	idiopathic scoliosis sclerostin osteocytes β-catenin Wnt signaling pathway Medicine R
Acceso en línea:	https://doaj.org/article/bc55d6f9420944c9b327bd16794d7814
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spelling	oai:doaj.org-article:bc55d6f9420944c9b327bd16794d78142021-11-25T18:01:24ZSclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis10.3390/jcm102252862077-0383https://doaj.org/article/bc55d6f9420944c9b327bd16794d78142021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5286https://doaj.org/toc/2077-0383Idiopathic scoliosis is a disorder of unknown etiology. Bone biopsies from idiopathic scoliosis patients revealed changes at cellular and molecular level. Osteocytic sclerostin is downregulated, and serum level of sclerostin is decreased. Osteocytes in idiopathic scoliosis appear to be less active with abnormal canaliculi network. Differentiation of osteoblasts to osteocytes is decelerated, while Wnt/β-catenin signaling pathway is overactivated and affects normal bone mineralization that leads to inferior mechanical properties of the bone, which becomes susceptible to asymmetrical forces and causes deformity of the spinal column. Targeting bone metabolism during growth by stimulating sclerostin secretion from osteocytes and restoring normal function of Wnt/β-catenin signaling pathway could, in theory, increase bone strength and prevent deterioration of the scoliotic deformity.Elias S. VasiliadisDimitrios Stergios EvangelopoulosAngelos KaspirisChristos VlachosSpyros G. PneumaticosMDPI AGarticleidiopathic scoliosissclerostinosteocytesβ-cateninWnt signaling pathwayMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5286, p 5286 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	idiopathic scoliosis sclerostin osteocytes β-catenin Wnt signaling pathway Medicine R
spellingShingle	idiopathic scoliosis sclerostin osteocytes β-catenin Wnt signaling pathway Medicine R Elias S. Vasiliadis Dimitrios Stergios Evangelopoulos Angelos Kaspiris Christos Vlachos Spyros G. Pneumaticos Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis
description	Idiopathic scoliosis is a disorder of unknown etiology. Bone biopsies from idiopathic scoliosis patients revealed changes at cellular and molecular level. Osteocytic sclerostin is downregulated, and serum level of sclerostin is decreased. Osteocytes in idiopathic scoliosis appear to be less active with abnormal canaliculi network. Differentiation of osteoblasts to osteocytes is decelerated, while Wnt/β-catenin signaling pathway is overactivated and affects normal bone mineralization that leads to inferior mechanical properties of the bone, which becomes susceptible to asymmetrical forces and causes deformity of the spinal column. Targeting bone metabolism during growth by stimulating sclerostin secretion from osteocytes and restoring normal function of Wnt/β-catenin signaling pathway could, in theory, increase bone strength and prevent deterioration of the scoliotic deformity.
format	article
author	Elias S. Vasiliadis Dimitrios Stergios Evangelopoulos Angelos Kaspiris Christos Vlachos Spyros G. Pneumaticos
author_facet	Elias S. Vasiliadis Dimitrios Stergios Evangelopoulos Angelos Kaspiris Christos Vlachos Spyros G. Pneumaticos
author_sort	Elias S. Vasiliadis
title	Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis
title_short	Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis
title_full	Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis
title_fullStr	Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis
title_full_unstemmed	Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis
title_sort	sclerostin and its involvement in the pathogenesis of idiopathic scoliosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bc55d6f9420944c9b327bd16794d7814
work_keys_str_mv	AT eliassvasiliadis sclerostinanditsinvolvementinthepathogenesisofidiopathicscoliosis AT dimitriosstergiosevangelopoulos sclerostinanditsinvolvementinthepathogenesisofidiopathicscoliosis AT angeloskaspiris sclerostinanditsinvolvementinthepathogenesisofidiopathicscoliosis AT christosvlachos sclerostinanditsinvolvementinthepathogenesisofidiopathicscoliosis AT spyrosgpneumaticos sclerostinanditsinvolvementinthepathogenesisofidiopathicscoliosis
_version_	1718411766977789952

Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis

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