GluN2A and GluN2B NMDA receptors use distinct allosteric routes

NMDA receptors are glutamate-gated ion channels essential for synapse maturation and plasticity. Here the authors show that GluN2A and GluN2B NMDA receptors — the two principal subtypes NMDARs in the adult CNS — operate through distinct long range allosteric mechanisms.

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Detalles Bibliográficos
Autores principales: Meilin Tian, David Stroebel, Laura Piot, Mélissa David, Shixin Ye, Pierre Paoletti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bc578a7cc0a845ae800db6cf37ab3c40
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Descripción
Sumario:NMDA receptors are glutamate-gated ion channels essential for synapse maturation and plasticity. Here the authors show that GluN2A and GluN2B NMDA receptors — the two principal subtypes NMDARs in the adult CNS — operate through distinct long range allosteric mechanisms.