GluN2A and GluN2B NMDA receptors use distinct allosteric routes

NMDA receptors are glutamate-gated ion channels essential for synapse maturation and plasticity. Here the authors show that GluN2A and GluN2B NMDA receptors — the two principal subtypes NMDARs in the adult CNS — operate through distinct long range allosteric mechanisms.

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Autores principales:	Meilin Tian, David Stroebel, Laura Piot, Mélissa David, Shixin Ye, Pierre Paoletti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc578a7cc0a845ae800db6cf37ab3c40
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spelling	oai:doaj.org-article:bc578a7cc0a845ae800db6cf37ab3c402021-12-02T16:35:46ZGluN2A and GluN2B NMDA receptors use distinct allosteric routes10.1038/s41467-021-25058-92041-1723https://doaj.org/article/bc578a7cc0a845ae800db6cf37ab3c402021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25058-9https://doaj.org/toc/2041-1723NMDA receptors are glutamate-gated ion channels essential for synapse maturation and plasticity. Here the authors show that GluN2A and GluN2B NMDA receptors — the two principal subtypes NMDARs in the adult CNS — operate through distinct long range allosteric mechanisms.Meilin TianDavid StroebelLaura PiotMélissa DavidShixin YePierre PaolettiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meilin Tian David Stroebel Laura Piot Mélissa David Shixin Ye Pierre Paoletti GluN2A and GluN2B NMDA receptors use distinct allosteric routes
description	NMDA receptors are glutamate-gated ion channels essential for synapse maturation and plasticity. Here the authors show that GluN2A and GluN2B NMDA receptors — the two principal subtypes NMDARs in the adult CNS — operate through distinct long range allosteric mechanisms.
format	article
author	Meilin Tian David Stroebel Laura Piot Mélissa David Shixin Ye Pierre Paoletti
author_facet	Meilin Tian David Stroebel Laura Piot Mélissa David Shixin Ye Pierre Paoletti
author_sort	Meilin Tian
title	GluN2A and GluN2B NMDA receptors use distinct allosteric routes
title_short	GluN2A and GluN2B NMDA receptors use distinct allosteric routes
title_full	GluN2A and GluN2B NMDA receptors use distinct allosteric routes
title_fullStr	GluN2A and GluN2B NMDA receptors use distinct allosteric routes
title_full_unstemmed	GluN2A and GluN2B NMDA receptors use distinct allosteric routes
title_sort	glun2a and glun2b nmda receptors use distinct allosteric routes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc578a7cc0a845ae800db6cf37ab3c40
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GluN2A and GluN2B NMDA receptors use distinct allosteric routes

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