Nucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix

Abstract Small synthetic molecules mimicking the three-dimensional structure of α-helices may find applications as inhibitors of therapeutically relevant protein-protein and protein-nucleic acid interactions. However, the design and use of multi-facial helix mimetics remains in its infancy. Here we...

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Autores principales: Cristina Medina-Trillo, Daniel M. Sedgwick, Lidia Herrera, Manuela Beltrán, Ángela Moreno, Pablo Barrio, Luis. M. Bedoya, José Alcamí, Santos Fustero, José Gallego
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bc755e05db704dcfa42be8ed46552b46
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