dCas9 regulator to neutralize competition in CRISPRi circuits

dCas9 regulator to neutralize competition in CRISPRi circuits

CRISPRi allows for the simultaneous control of many genes, however the sgRNAs compete for binding to dCas9. Here the authors design a dCas9 concentration regulator to allow independent regulation of multiple genes.

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Autores principales: Hsin-Ho Huang, Massimo Bellato, Yili Qian, Pablo Cárdenas, Lorenzo Pasotti, Paolo Magni, Domitilla Del Vecchio
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/bc77626575304f0082d2047b7dc45282
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