Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

Fanconi anemia is a complex disease affecting multiple DNA repair proteins that resolve DNA crosslinks which can block vital processes. Here the authors use parallel genome-wide screens that identify the BLM helicase complex as a suppressor of Fanconi anemia phenotypes.

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Autores principales:	Martin Moder, Georgia Velimezi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Joana Ferreira da Silva, Lydia Robinson-Garcia, Fiorella Schischlik, Rastislav Slavkovsky, Robert Kralovics, Michael Schuster, Christoph Bock, Trey Ideker, Stephen P. Jackson, Jörg Menche, Joanna I. Loizou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bca0a3f08cd24bcb930f0ad1a08874af
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spelling	oai:doaj.org-article:bca0a3f08cd24bcb930f0ad1a08874af2021-12-02T14:42:21ZParallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia10.1038/s41467-017-01439-x2041-1723https://doaj.org/article/bca0a3f08cd24bcb930f0ad1a08874af2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01439-xhttps://doaj.org/toc/2041-1723Fanconi anemia is a complex disease affecting multiple DNA repair proteins that resolve DNA crosslinks which can block vital processes. Here the authors use parallel genome-wide screens that identify the BLM helicase complex as a suppressor of Fanconi anemia phenotypes.Martin ModerGeorgia VelimeziMichel OwusuAbdelghani MazouziMarc WiednerJoana Ferreira da SilvaLydia Robinson-GarciaFiorella SchischlikRastislav SlavkovskyRobert KralovicsMichael SchusterChristoph BockTrey IdekerStephen P. JacksonJörg MencheJoanna I. LoizouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Moder Georgia Velimezi Michel Owusu Abdelghani Mazouzi Marc Wiedner Joana Ferreira da Silva Lydia Robinson-Garcia Fiorella Schischlik Rastislav Slavkovsky Robert Kralovics Michael Schuster Christoph Bock Trey Ideker Stephen P. Jackson Jörg Menche Joanna I. Loizou Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia
description	Fanconi anemia is a complex disease affecting multiple DNA repair proteins that resolve DNA crosslinks which can block vital processes. Here the authors use parallel genome-wide screens that identify the BLM helicase complex as a suppressor of Fanconi anemia phenotypes.
format	article
author	Martin Moder Georgia Velimezi Michel Owusu Abdelghani Mazouzi Marc Wiedner Joana Ferreira da Silva Lydia Robinson-Garcia Fiorella Schischlik Rastislav Slavkovsky Robert Kralovics Michael Schuster Christoph Bock Trey Ideker Stephen P. Jackson Jörg Menche Joanna I. Loizou
author_facet	Martin Moder Georgia Velimezi Michel Owusu Abdelghani Mazouzi Marc Wiedner Joana Ferreira da Silva Lydia Robinson-Garcia Fiorella Schischlik Rastislav Slavkovsky Robert Kralovics Michael Schuster Christoph Bock Trey Ideker Stephen P. Jackson Jörg Menche Joanna I. Loizou
author_sort	Martin Moder
title	Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia
title_short	Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia
title_full	Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia
title_fullStr	Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia
title_full_unstemmed	Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia
title_sort	parallel genome-wide screens identify synthetic viable interactions between the blm helicase complex and fanconi anemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bca0a3f08cd24bcb930f0ad1a08874af
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Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

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