Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats

Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds,...

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Autores principales: Natália T.M. Calzerra, Mayara P. Melo, Pablo F. Santos, Kívia S. Assis, Priscilla M.P. Maciel, Renata L.P. Vieira, Fátima de L.A.A. Azevedo, Angela M.T.M. Cordeiro, Bruno R.L.A. Meireles, Islania G.A. Araújo, Robson C. Veras, Isac A. Medeiros
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
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Acceso en línea:https://doaj.org/article/bcb87fe0e79543299d747e37e3f3a6db
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Sumario:Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds, such as gentisic acid, catechin, and resveratrol were identified in LRW-RSCS using high-performance liquid chromatography. LRW-RSCS presented anti-radical activity. Six-week treatment of SHR with LRW-RSCS (100 or 300 mg/Kg/day intra-gastrically) reduced blood pressure and hypercontractility, and improved mesenteric resistance artery endothelial function. The protective effect of LRW-RSCS on endothelial function, mediated relaxation involving both higher endothelial-NO and -EDHF. LRW-RSCS intake reduced vessel wall thickness, media-to-lumen ratio, collagen vascular deposition, and vessel oxidative stress. LRW-RSCS also attenuated platelet hyper aggregation and ROS generation. The results demonstrate that LRW-RSCS from Northeastern Brazil presents cardiovascular protective effect in SHR, at least in part by decreasing oxidative stress.