Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats

Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds,...

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Autores principales:	Natália T.M. Calzerra, Mayara P. Melo, Pablo F. Santos, Kívia S. Assis, Priscilla M.P. Maciel, Renata L.P. Vieira, Fátima de L.A.A. Azevedo, Angela M.T.M. Cordeiro, Bruno R.L.A. Meireles, Islania G.A. Araújo, Robson C. Veras, Isac A. Medeiros
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Essential hypertension Brazilian red wine Endothelial dysfunction Vascular alterations Mesenteric resistance arteries Spontaneously hypertensive rats Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/bcb87fe0e79543299d747e37e3f3a6db
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spelling	oai:doaj.org-article:bcb87fe0e79543299d747e37e3f3a6db2021-12-02T05:00:16ZCardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats1756-464610.1016/j.jff.2021.104868https://doaj.org/article/bcb87fe0e79543299d747e37e3f3a6db2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S175646462100517Xhttps://doaj.org/toc/1756-4646Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds, such as gentisic acid, catechin, and resveratrol were identified in LRW-RSCS using high-performance liquid chromatography. LRW-RSCS presented anti-radical activity. Six-week treatment of SHR with LRW-RSCS (100 or 300 mg/Kg/day intra-gastrically) reduced blood pressure and hypercontractility, and improved mesenteric resistance artery endothelial function. The protective effect of LRW-RSCS on endothelial function, mediated relaxation involving both higher endothelial-NO and -EDHF. LRW-RSCS intake reduced vessel wall thickness, media-to-lumen ratio, collagen vascular deposition, and vessel oxidative stress. LRW-RSCS also attenuated platelet hyper aggregation and ROS generation. The results demonstrate that LRW-RSCS from Northeastern Brazil presents cardiovascular protective effect in SHR, at least in part by decreasing oxidative stress.Natália T.M. CalzerraMayara P. MeloPablo F. SantosKívia S. AssisPriscilla M.P. MacielRenata L.P. VieiraFátima de L.A.A. AzevedoAngela M.T.M. CordeiroBruno R.L.A. MeirelesIslania G.A. AraújoRobson C. VerasIsac A. MedeirosElsevierarticleEssential hypertensionBrazilian red wineEndothelial dysfunctionVascular alterationsMesenteric resistance arteriesSpontaneously hypertensive ratsNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 88, Iss , Pp 104868- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Essential hypertension Brazilian red wine Endothelial dysfunction Vascular alterations Mesenteric resistance arteries Spontaneously hypertensive rats Nutrition. Foods and food supply TX341-641
spellingShingle	Essential hypertension Brazilian red wine Endothelial dysfunction Vascular alterations Mesenteric resistance arteries Spontaneously hypertensive rats Nutrition. Foods and food supply TX341-641 Natália T.M. Calzerra Mayara P. Melo Pablo F. Santos Kívia S. Assis Priscilla M.P. Maciel Renata L.P. Vieira Fátima de L.A.A. Azevedo Angela M.T.M. Cordeiro Bruno R.L.A. Meireles Islania G.A. Araújo Robson C. Veras Isac A. Medeiros Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats
description	Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds, such as gentisic acid, catechin, and resveratrol were identified in LRW-RSCS using high-performance liquid chromatography. LRW-RSCS presented anti-radical activity. Six-week treatment of SHR with LRW-RSCS (100 or 300 mg/Kg/day intra-gastrically) reduced blood pressure and hypercontractility, and improved mesenteric resistance artery endothelial function. The protective effect of LRW-RSCS on endothelial function, mediated relaxation involving both higher endothelial-NO and -EDHF. LRW-RSCS intake reduced vessel wall thickness, media-to-lumen ratio, collagen vascular deposition, and vessel oxidative stress. LRW-RSCS also attenuated platelet hyper aggregation and ROS generation. The results demonstrate that LRW-RSCS from Northeastern Brazil presents cardiovascular protective effect in SHR, at least in part by decreasing oxidative stress.
format	article
author	Natália T.M. Calzerra Mayara P. Melo Pablo F. Santos Kívia S. Assis Priscilla M.P. Maciel Renata L.P. Vieira Fátima de L.A.A. Azevedo Angela M.T.M. Cordeiro Bruno R.L.A. Meireles Islania G.A. Araújo Robson C. Veras Isac A. Medeiros
author_facet	Natália T.M. Calzerra Mayara P. Melo Pablo F. Santos Kívia S. Assis Priscilla M.P. Maciel Renata L.P. Vieira Fátima de L.A.A. Azevedo Angela M.T.M. Cordeiro Bruno R.L.A. Meireles Islania G.A. Araújo Robson C. Veras Isac A. Medeiros
author_sort	Natália T.M. Calzerra
title	Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats
title_short	Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats
title_full	Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats
title_fullStr	Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats
title_full_unstemmed	Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats
title_sort	cardiovascular protection effect of a northeastern brazilian lyophilized red wine in spontaneously hypertensive rats
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/bcb87fe0e79543299d747e37e3f3a6db
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Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats

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