Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1...

Full description

Saved in:
Bibliographic Details
Main Authors: Teng Teng, Jennifer HC Tsai, Xiaoling Puyang, Michael Seiler, Shouyong Peng, Sudeep Prajapati, Daniel Aird, Silvia Buonamici, Benjamin Caleb, Betty Chan, Laura Corson, Jacob Feala, Peter Fekkes, Baudouin Gerard, Craig Karr, Manav Korpal, Xiang Liu, Jason T. Lowe, Yoshiharu Mizui, James Palacino, Eunice Park, Peter G. Smith, Vanitha Subramanian, Zhenhua Jeremy Wu, Jian Zou, Lihua Yu, Agustin Chicas, Markus Warmuth, Nicholas Larsen, Ping Zhu
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/bcd02552d59140f1871d75acbfffec14
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/bcd02552d59140f1871d75acbfffec14

Similar Items