Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1...
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Nature Portfolio
2017
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oai:doaj.org-article:bcd02552d59140f1871d75acbfffec142021-12-02T15:37:05ZSplicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex10.1038/ncomms155222041-1723https://doaj.org/article/bcd02552d59140f1871d75acbfffec142017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15522https://doaj.org/toc/2041-1723A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex.Teng TengJennifer HC TsaiXiaoling PuyangMichael SeilerShouyong PengSudeep PrajapatiDaniel AirdSilvia BuonamiciBenjamin CalebBetty ChanLaura CorsonJacob FealaPeter FekkesBaudouin GerardCraig KarrManav KorpalXiang LiuJason T. LoweYoshiharu MizuiJames PalacinoEunice ParkPeter G. SmithVanitha SubramanianZhenhua Jeremy WuJian ZouLihua YuAgustin ChicasMarkus WarmuthNicholas LarsenPing ZhuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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Science Q Teng Teng Jennifer HC Tsai Xiaoling Puyang Michael Seiler Shouyong Peng Sudeep Prajapati Daniel Aird Silvia Buonamici Benjamin Caleb Betty Chan Laura Corson Jacob Feala Peter Fekkes Baudouin Gerard Craig Karr Manav Korpal Xiang Liu Jason T. Lowe Yoshiharu Mizui James Palacino Eunice Park Peter G. Smith Vanitha Subramanian Zhenhua Jeremy Wu Jian Zou Lihua Yu Agustin Chicas Markus Warmuth Nicholas Larsen Ping Zhu Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex |
| description |
A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex. |
| format |
article |
| author |
Teng Teng Jennifer HC Tsai Xiaoling Puyang Michael Seiler Shouyong Peng Sudeep Prajapati Daniel Aird Silvia Buonamici Benjamin Caleb Betty Chan Laura Corson Jacob Feala Peter Fekkes Baudouin Gerard Craig Karr Manav Korpal Xiang Liu Jason T. Lowe Yoshiharu Mizui James Palacino Eunice Park Peter G. Smith Vanitha Subramanian Zhenhua Jeremy Wu Jian Zou Lihua Yu Agustin Chicas Markus Warmuth Nicholas Larsen Ping Zhu |
| author_facet |
Teng Teng Jennifer HC Tsai Xiaoling Puyang Michael Seiler Shouyong Peng Sudeep Prajapati Daniel Aird Silvia Buonamici Benjamin Caleb Betty Chan Laura Corson Jacob Feala Peter Fekkes Baudouin Gerard Craig Karr Manav Korpal Xiang Liu Jason T. Lowe Yoshiharu Mizui James Palacino Eunice Park Peter G. Smith Vanitha Subramanian Zhenhua Jeremy Wu Jian Zou Lihua Yu Agustin Chicas Markus Warmuth Nicholas Larsen Ping Zhu |
| author_sort |
Teng Teng |
| title |
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex |
| title_short |
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex |
| title_full |
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex |
| title_fullStr |
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex |
| title_full_unstemmed |
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex |
| title_sort |
splicing modulators act at the branch point adenosine binding pocket defined by the phf5a–sf3b complex |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/bcd02552d59140f1871d75acbfffec14 |
| work_keys_str_mv |
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1718386255292530688 |